BMS657 Synthetic Biology UITM Assignment Answer Malaysia

BMS657 Synthetic Biology is an advanced course offered at Universiti Teknologi MARA (UITM) in Malaysia. This  course explores the exciting field of synthetic biology, which involves applying engineering principles to design and construct biological systems using DNA parts from various organisms or synthetic genetic sequences.

Throughout the course, students will delve into the fundamental concepts of synthetic biology and its wide-ranging applications in various industries, including biotechnology, bioremediation, agriculture, and medicine.We will gain a comprehensive understanding of how to manipulate biological components to create novel systems with desired functionalities.

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Assignment Activity 1 : Illustrate the principles, techniques and mechanism of synthetic biology

Synthetic biology is an interdisciplinary field that combines principles from biology, engineering, and computer science to design and construct new biological parts, devices, and systems, or to modify existing biological systems for specific purposes. The core principles, techniques, and mechanisms of synthetic biology include:

• DNA Synthesis and Assembly: Synthetic biology starts with the design of genetic sequences using computer algorithms. These sequences are then chemically synthesized to create artificial DNA. DNA assembly techniques like PCR (Polymerase Chain Reaction) and DNA sequencing are employed to manipulate and analyze genetic information.
• Standardization: To facilitate genetic engineering, synthetic biology employs the standardization of genetic parts, known as BioBricks. These are well-characterized genetic components, such as promoters, terminators, and coding sequences, that can be easily combined to create new genetic circuits.
• Genetic Circuits and Pathways: Synthetic biologists build genetic circuits by connecting various genetic components. These circuits can be designed to perform specific functions, similar to electronic circuits. By combining genetic elements, they can construct complex biological pathways to achieve desired outcomes.
• CRISPR-Cas9 Technology: The CRISPR-Cas9 system is a powerful genome editing tool widely used in synthetic biology. It allows precise modification of DNA sequences, enabling the addition, deletion, or alteration of genes in a targeted manner.
• Directed Evolution: Synthetic biology often employs directed evolution to optimize biological systems. This technique involves creating a diverse population of organisms, subjecting them to selective pressures, and then selecting the ones with the desired characteristics.
• Computational Modeling: Computer simulations and computational models are used to predict the behavior of genetic circuits and other biological systems before they are physically constructed. This helps in reducing trial-and-error experiments.

Assignment Activity 2 :UElaborate on the applications of synthetic biology technology

Synthetic biology has numerous applications across various industries and fields. Some of the key applications include:

• Medicine and Pharmaceuticals: Synthetic biology offers the potential to create new drugs and therapies through the design of novel proteins, antibodies, and pharmaceutical compounds. It also aids in the development of personalized medicine and targeted drug delivery systems.
• Agriculture: Synthetic biology can be used to enhance crop yields, improve disease resistance in plants, and develop bioengineered organisms to produce sustainable agricultural products.
• Bioenergy: Synthetic biology is used to engineer microorganisms that can efficiently produce biofuels, such as bioethanol and biodiesel, from renewable resources.
• Environmental Remediation: Synthetic biology plays a role in environmental conservation by creating organisms that can help clean up pollutants, degrade plastics, and remediate contaminated sites.
• Bioremediation: Microorganisms can be designed to remove toxic substances from industrial waste and contaminated water bodies.
• Biotechnology: Synthetic biology is utilized in producing enzymes, chemicals, and bio-based materials more sustainably and cost-effectively.
• Biosensors: Synthetic biology enables the development of biosensors that can detect specific molecules or environmental changes, useful in healthcare, environmental monitoring, and food safety.
• Living Computers: Research is ongoing to create biological computers using synthetic biology, allowing computations and data storage within living cells.

Assignment Task 3 : Perform laboratory experiments on tissue cultures and biological controls.

The merits and hazards of synthetic biology raise several ethical and professional considerations:

Merits:

• Improved Healthcare: Synthetic biology advancements can lead to better medical treatments and cures for diseases.
• Sustainable Solutions: It offers eco-friendly alternatives to traditional industrial processes, reducing the ecological impact.
• Food Security: Enhanced crops can address food shortages and improve global nutrition.
• Environmental Protection: Bioremediation can aid in reducing pollution and restoring ecosystems.

Hazards:

• Biosecurity: Misuse of synthetic biology can lead to the creation of harmful pathogens or bioweapons.
• Unintended Consequences: Genetic modifications may have unforeseen effects on ecosystems or human health.
• Equity: Access to synthetic biology technologies should be equitable to avoid exacerbating societal inequalities.
• Patents and Ownership: Ethical issues arise concerning the patenting and commercialization of synthetic biology products.

Professionalism:

• Transparency: Researchers and practitioners should be transparent about their work and potential risks.
• Peer Review: Scientific advancements in synthetic biology should undergo rigorous peer review.
• Compliance: Adherence to ethical guidelines and safety protocols is essential to prevent harmful outcomes.
• Responsible Innovation: Practitioners should consider the long-term impacts of their work on society and the environment.

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